Medically reviewed on April 4, 2024 by Jordan Stachel, M.S., RDN, CPT. To give you technically accurate, evidence-based information, content published on the Everlywell blog is reviewed by credentialed professionals with expertise in medical and bioscience fields.
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Doxycycline is a kind of tetracycline antibiotic that’s prescribed to treat many different kinds of infections. [1] For instance, healthcare providers may use it to treat cases of acne or rosacea, though it’s also used to treat dangerous bacterial infections like anthrax. [1]
When you’re prescribed doxycycline (or any other antibiotic), it isn’t always clear what lifestyle adjustments you’ll need to make while using it. To that end, you may be wondering, can you drink alcohol on antibiotics like doxycycline?
In general, it is considered safe to drink alcohol during a doxycycline course. [2] However, it’s important to be aware of the drawbacks and risks of using doxycycline and alcohol together. At present, the relationship between antibiotics and alcohol is largely considered under-researched. [2] That said, having a general grasp of the interactions and potential risks can help support a more efficient recovery—without causing any undue harm to your health in the process.
Antibiotics can be classed on a spectrum based on how many bacteria they target:
Doxycycline is generally considered a moderate or broad-spectrum antibiotic. [3, 1] Because they deal with a broader range of bacteria, broad-spectrum antibiotics like doxycycline carry some risks. [4]
The main concern is that taking these antibiotics makes it more likely for the bacteria in your body to become resistant to your medication (this is known as antibiotic resistance). [4] This occurs when microorganisms adapt and evolve in your body, making antibiotic treatment much less effective or ineffective over time.
To lower your risk of developing resistance, it may be best to make some temporary lifestyle changes to help your antibiotic medication act as effectively as possible. For some people, this may mean avoiding recreational substances like alcohol, which can interfere with antibiotics’ ability to treat the bacterial infection. [2]
Aside from potential long-term health consequences, another consideration for mixing alcohol and antibiotics is that alcohol may elevate your risk of potential antibiotic side effects. [5] Some people also report that drinking alcohol makes existing antibiotic side effects worse. These include [5]:
Research indicates that certain antibiotics, like erythromycin, are definitively inhibited when taken with alcohol. [2] Data also suggests that people with a history of alcohol use disorder or chronic alcoholism are more likely to experience reduced efficacy of doxycycline, specifically. [2]
Alcohol use also introduces variables that can indirectly interfere with infection recovery. For instance, alcohol can adversely impact sleep and energy levels, making it more difficult for your body to recover from infection. [5] For this reason, many people elect to avoid alcohol until they’ve completed their prescribed course of antibiotics. [5]
The current data suggests that many antibiotics won’t cause toxicity or adverse reactions if used together, though there are exceptions. [2]
Antibiotics that are generally considered safe to use alongside alcohol include [2]:
Other antibiotics can result in severe reactions when mixed with or when combined with alcohol. These include [2]:
One of the largest concerns for mixing the aforementioned antibiotics with alcohol is the consequences for your liver. [2] Like other antibiotics, drinking alcohol can also heighten your risk of experiencing potential side effects unique to each type of medication, which may be physical as well as mental or mood-related. [2]
Sometimes, only certain types of alcoholic beverages carry a risk of interfering with antibiotics. For instance, linezolid (also known as Zyvox) has only been found to produce adverse reactions when combined with specific alcoholic beverages like tap beer and red wine. [5]
Certain antibiotics may yield few or no side effects when combined with mild or moderate drinking. However, people who struggle with heavy or binge drinking, or chronic alcohol use disorder, may experience more health consequences.
The National Institute on Alcohol Abuse and Alcoholism currently defines moderate drinking as [7]:
If you’ve been prescribed antibiotics and are struggling to stop drinking, your healthcare provider can help you design a plan for treating your infection without harming your overall health. You might also consider speaking to them about options for treating struggles with substance abuse.
The primary guideline for using antibiotics safely is to always ask your healthcare provider before deciding to use alcohol or another recreational substance while taking them. [7]
In fact, to protect all areas of your well-being, it’s recommended you ask for information about [5]:
Ultimately, your healthcare provider should have the final word regarding the safety of alcohol and antibiotic use. With that, there are several general guidelines for optimizing antibiotic efficacy and helping you make the safest and speediest recovery possible.
One 2020 study showed that prescription labels do not necessarily provide universal advisories about mixing alcohol and certain antibiotics. [2] For instance, while one pharmacy may advise users to “limit intake of alcoholic beverages,” others may not provide a warning at all. [2]
With that said, if you’re prescribed antibiotics and are considering drinking alcohol, it’s a wise idea to reach out to a healthcare provider for clearance. They can assess your specific prescription medication, alcohol use habits, and unique health history to arrive at the best recommendation possible.
If you’re eliminating alcohol to enhance the efficacy of your prescribed antibiotics, you might consider avoiding foods that can have a similar effect. These include:
While some potential side effects of antibiotics are mild and normal, others may be cause for concern. These include [1]:
Symptoms like these typically indicate an allergy to your prescribed antibiotic. They require emergency treatment by a healthcare provider to curb severe and even fatal health consequences.
It’s important to never use someone else’s antibiotics, even if you’ve been diagnosed with the same infection or have been using the same type of medication.
Antibiotic prescriptions are highly personal, prescribed according to your unique health history. Moreover, prescriptions can differ in:
Using anyone else’s antibiotics can raise your likelihood of developing resistance. If you get an infection in the future, resistance can result in fewer treatment options. In this way, avoiding using someone else's prescription medication can help prevent overuse.
No matter what type of infection you have, never use antibiotics without a prescription. Not only will obtaining a prescription help prevent resistance, but it can also help ensure:
Ultimately, obtaining a prescription promotes the best possible health outcome—for both your short-term recovery and your long-term health. If you’re unable to meet with a primary healthcare provider in person, you may still be able to obtain prescription services through telehealth services.
No matter what health concerns you’re facing, Everlywell can connect you to the right resources for staying informed about your well-being. With online virtual care visits and online prescription services, Everlywell makes caring for your complete health more convenient and cost-effective.
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Can You Take Probiotics With Antibiotics?
Do Antibiotics Make You Tired? Antibiotic Insights
Can You Drink Alcohol on Antibiotics? Potential Risks